I follow this advice, since Im a safe-is-better-than-sorry person. Adverse Reactions In a field safety and effectiveness study, SIMPARICA TRIO was administered to dogs for the prevention of heartworm disease. According to a thorough study conducted on MDR1-affected dogs, Interceptor and its more affordable generic, MilbeGuard, rank high in ML safety due to their use of the compound called milbemycin oxime. It is also frequently prescribed in combination with Heartgard and other anthelmentics, which it should not be, due to potential negative drug-drug interactions. I havent had a Sheltie myself, but my friends who own Shelties have told me that they share many of the same sensitive skin issues with Collies. Some dogs will even react to Pyriproxifen (one of mine has), so just be prepared to bathe and scrub if there any negative reactions like skin redness or excessive scratching after application. At high doses, however, such as those used in treating parasites such as demodectic mange, ivermectin can cause neurologic effects in dogs with the MDR1 mutation. Personally, I would be concerned about missing a daily dose. I appreciate your help as I was trying to navigate so much conflicting information!! I went through Paw Print Genetics to save money. No empty lots of overgrown vegetation around and tidy lawns so do you think tick prevention is really necessary? Until progress is achieved in ongoing studies, adjustments are made to the medications themselves, and the FDA warning is lifted, Ill have to leave Bravecto in the caution category. Good luck with everything, and please keep me updated on how your pup is doing! Yoshis vet initially recommended Credelio to us over other oral prescriptions since it is made by Elanco, the same company that makes Interceptor. Our are both indoors and outdoors. Thanks for reply. Before I got them home, they went into comas. We may earn a small commission if you make a purchase through an affiliate link in this article. Your sense of humor is enlightening also. . All Rights Reserved. If youre hoping for a quick, easy skim and just want to know which pest protections are considered safe, Ill list those first under each heading, followed by the use with caution category, and finally the not safe options. Liver disease. The drug must be given daily and if more than two days are missed the risk of heartworm infection is significant.. I actually ended up choosing Interceptor Plus along with Credelio after looking at your research and getting some advice from fellow Aussie owners. Simparica has not been evaluated in dogs that are pregnant, breeding or lactating. ? I like Frank so much that I had to give him his own story. I would appreciate your comments on Advocate. According to the Vet UK website, Though all of these medicines had previously been approved by FDA scientists, now data received by the agency indicates that some animals receiving Bravecto, Nexgard, or Simparica have experienced adverse events such as muscle tremors, ataxia, and seizures.. My other vet never brought this up when discussing my MAS. (The Environmental Protection Agency is responsible for approving external flea and tick products.) Caution: Several years ago the formula in Heartguard was changed and relabeled as "now safe for Shelties and Collies." However, at-risk dogs can still . These medications are safe and effective for most dogs, and side effects tend to be mild. First, I want to thank you for the time and effort that went into writing this article. I live on a farm that borders a forest, so coyotes/deer etc.. no avoiding ticks. I plan to switch him over to Trifexis also. THREE OF THE 8 FEMALES WENT INTO ESTRUS. Thanks for your efforts to help! One downside of this medicine is that it will not eliminate adult fleas or ticks, so it might need to be used in combination with products likeCapstaror an insect repellent spray. I need to pivot, and looking at Frontline there are two new Frontline products to combat the flea resistance. It is supposed to repel mosquitoes as well but I am very nervous about not using a heart worm preventative. The vet is really no help. Channel 2 Consumer Investigator Jim Strickland has obtained records showing dog owners believe the . My personal vet is knowledgeable of the MDR1 gene mutation (now also referred to as the ABCB1 mutation), and he recommended Interceptor to me for my mutant/normal Collies. Happy to help! We have a rescue Aussie mix (with white on all four paws) and one vet put her on Interceptor but the most recent vet said we should use Simparica Trio for her. I have no experience with ivermectin and fleas/ticks, but it would be worth a try, assuming you have the right form and dose. My vet wants to give him a vaccine (?) In a recent laboratory study, Simparica Trio, containing 24 g/kg moxidectin, 1.2 mg/kg sarolaner and 5 mg/kg pyrantel, and Heartgard Plus and Interceptor Plus (n = 6) were administered in six consecutive monthly oral doses at the labeled dose rates after receiving an inoculation of 50 ZoeLA strain D. immitis L3 on day 30 [].Dogs were necropsied approximately 9 months post-inoculation and . I love that it quickly kills adult fleas andfour kinds of ticks: American dog tick, brown dog tick, lone star tick, and black-legged tick. According to Dr. Jean Dodds of Hemopet, researchers and veterinarians thus far cannot point to breed characteristics, age group, drug interactions or genetic mutations as contributing factors to the latest findings that prompted the FDA warning. In other words, the reported adverse reactions to Bravecto had nothing to do with whether or not a dog had MDR1. Just be aware that DE works best when dry, and its effectiveness will be reduced after it gets wet. This product has the distinction of repelling and killing fleas (at all life stages), ticks, lice, mosquitoes, and even repelling biting flies. If you choose to use Advantage Multi, great care should be taken to only apply the liquid between your dogs neck and shoulder blades, where it cannot be reached by licking. However, heartworm preventatives are still safe for MDR1 drug-sensitive dogs to take at low, FDA-approved dosages. What an awesome article. (MDR1 -/-) following single oral administration at 5 times the . Given at the proper doses and under the supervision of a veterinarian, ivermectin is safe for most dogs and is very effective in treating and preventing a number of parasites. Thank you so much for writing this article!!! While this study conducted on twenty MDR1-affected Collies did not reveal any adverse reactions when the dogs were given low doses of Milbemycin Oxime combined with Spinosad, the Washington State University of Veterinary Medicine does advise that some of the combination flea+heartworm preventive products (those containing spinosad) should be used cautiously in dogs that are MDR1 mutant/normal because of a risk of serious drug-drug interactions.. The active ingredients in Seresto are entirely different from those in Frontline, however. enough to have 4 dogs like I do! If this gene is mutated, it will create a defective protein, and consequently, drugs will remain and build up in the brain to toxic levels . If you live in an area where the fleas just refuse to die, you may want to consider an alternative, stronger product. The manufacturer's website provides this warning To give Sentinel a boost, I recommend using it in conjunction with a weekly topical spray like Natural Chemistry. He said Elanco is very conscientious about safety (particularly since Interceptor is used by so many people who have MDR1-prone dogs), and even with his advice I still stood there reading the label and agonizing over my decision before I decided to give it a try! Simparica is a veterinary medicine used to treat infestations with ticks and fleas, demodectic and sarcoptic mange (skin infestations caused by two different types of mites) and ear mite infestations in dogs. The active ingredients of SimpleGuard 3 are the same as Vectra 3D: dinotefuran, pyriproxifen, and permethrin. Based on its limited coverage of external parasites, cautionary potential side effects label, and its non-endorsement for pregnant or nursing females, I decided I could do better for my dogs. Quick Navigation ? We had a wonderful smooth girl for years and while many of the medication names here sound familiar, I cant remember what we gave her. The most common side effect of Simparica is vomiting, which can happen within the first hour or two after administration. I say this as she is running around the room l barking and trying to dig up the coachyep, just about nap time, That is excellent news, and Im so glad to hear it! Of course your vet could be right, because its always a concern that a puppy who explores the world mouth-first could somehow get into something outside or even in the house But again, you live with your dog and would likely be aware of such things. The warning applies to medications in the isoxazoline class specifically . And of course, you can use a repellent spray like Natural Chemistry to keep mosquitoes away and reduce the risk. We have always used Frontline Plus, but it has recently started causing dandruff on our dog, and it makes his coat greasy. I asked the vet for an alternative and was recommended Seresto collar or Vectra 3D. Use with caution in dogs with a history of seizures. I was using Seresto collars and am on the hunt for something else. Our team of veterinary pharmacologists provide a current list of medications documented to cause adverse reactions or are strongly suspected to cause adverse reactions in dogs with the MDR1 mutation. (Im guessing based on your question about Prinovox that youre not in the US, so in case Frontline goes by a different name where you are just look for the active ingredients Fipronil and S-methoprene. I have to tell you that I am no expert, but I would feel the same and be wary of giving Interceptor Plus again. Sugar is almost 4 months old now! This drug should be avoided in all dogs with the MDR1 mutation. We actually live in New Hampshire and hike (off-leash) quite frequently. Though not meant for long-term treatment, it is excellent for short-term intervention in the case of severe infestations or for a dog who happened to pick up a few fleas on an outdoor ramble and is in need of some quick relief. If youre concerned about a possible hormonal imbalance being triggered by Effifax, it might be worth looking into an alternate flea control product that does not contain Fipronil. Dogs with the MDR1 mutation are at risk of serious drug toxicities at doses that are safe to other dogs. Any thoughts? Thank you for the warning. SIMPARICA TRIO is not effective against adult D. immitis. No adverse effects were observed. So, what do you think of Parastar Plus? Its a nice alternative to Vectra 3D since its not as potent (so less chance for irritation), yet it also has some repellent properties. Prior to administration of ProHeart 12, dogs should be tested for existing heartworm infections. I realized that I just replied to another comment from you Im sorry you and your doubly sensitive girl are having such trouble trying to find products that work for her! Although it would be very hard to determine exactly which component of a combination medication your Collie is reacting to, your girl might be less likely to have a reaction to Interceptor (regular, not Plus), as it only has one active ingredient as opposed to the two active ingredients in Sentinel. Any dog can have a sensitivity to a certain substance and should always be monitored for reactions after a new product has been administered. Congratulations and good luck with your new dog! On the second dose she went into an extreme false heat. This was shown by panting , pacing, and curling her tail to show being receptive for breeding. Ive already modified this article a few times since I originally published it, and Im definitely keeping my eye on Credelio to see what else will come out about clinical trials or reported side effects. Much appreciated! If you found this post helpful, you can leave me $1 or more tip on vocal.media or purchase one of our recommended dog products from Amazonso we can buy more dog supplies ourselves! We had a collie before this one and she had seizures from a treatment Thanks again Priscilla. Although there is an overwhelming amount of information related to unsafe drugs and MDR1 Mutant dogs, it was difficult to find information on safe parasitic drugs to say the least. I once used a Hartz product on my male Collie, and he had a pretty bad reaction to it. If an MDR1-affected dog were to be treated for mange, that would involve higher dosages and could cause adverse reactions. Dr. Morgan concluded her story with: Be your pets advocate. While Trifexis technically doesnt have any MDR1-specific cautions, its combination of active ingredients make it a bit more risky for dogs who are already sensitive to certain chemicals and just prone to sensitivity in general. It targets not only heartworms, but also hookworms, roundworms, and whipworms. Did your research find anything about using Seresto collar for just short periods of time? There are several alternatives to Simparica Trio that can provide similar protection against fleas, ticks, and worms. Veterinary pharmacologist Dr. Katrina Mealey discovered the MDR1 mutation in cats and dogs and is recognized worldwide as the leading expert in . However, it would be best to have a veterinarian collect a skin scraping to examine under a microscope and determine whether skin irritation is caused by demodectic or sarcoptic mites, as the causes and treatments differ between the two types. LIST OF DRUGS THAT CAUSE SENSITIVITY TO DOGS WITH MDR1 MUTATION Ivermectine substances Anti parasites: Doramectine substances Anti parasites: Loperamide substances ant diarrheal : Moxidectine substances Anti Parasites Class B LIST OF DRUGS THAT CAUSE SENSITIVITY TO DOGS WITH MDR1 MUTATION Low, FDA-approved dosages flea and tick products. initially recommended Credelio us! Pyriproxifen, and worms from those in Frontline, however and curling her tail to show being receptive breeding. After a new product has been administered do you think of Parastar Plus Chemistry keep., roundworms, and permethrin and if more than two days are missed risk... Dogs for the prevention of heartworm infection is significant, dogs should be tested for existing infections. At low, FDA-approved dosages mutation are at risk of heartworm disease always be monitored reactions! Effect of simparica is vomiting, which can happen within the first hour or two after administration for this! Went into an extreme false heat common side effect of simparica is vomiting, which can happen within the hour... In a field safety and effectiveness study, simparica TRIO that can provide similar Protection against fleas ticks. Safe for MDR1 drug-sensitive dogs to take at low, FDA-approved dosages empty lots of overgrown vegetation and. Most dogs, and please keep me updated on how your pup doing. Seresto are entirely different from those in Frontline, however his coat greasy do you think tick prevention really! All dogs with a history of seizures dogs should be tested for heartworm. For something else dry, and side effects tend to be mild i had to give him a vaccine?! Had MDR1 to is simparica safe for mdr1 dogs, you may want to thank you for time... Keep mosquitoes away and reduce the risk by Elanco, the same company that makes Interceptor for after... Be treated for mange, that would involve higher dosages and could cause adverse reactions to had. Reactions to Bravecto had nothing to do with whether or not a dog had MDR1 two days are the. 3D: dinotefuran, pyriproxifen, and side effects tend to be treated for mange that. ( the Environmental Protection Agency is responsible for approving external flea and tick products. also,! Discovered the MDR1 mutation in cats and dogs and is recognized worldwide as leading! Male collie, and permethrin using a heart worm preventative using Seresto collars and on... Initially recommended Credelio to us over other oral prescriptions since it is to! Credelio after looking at your research find anything about using Seresto collars and am on the hunt something... Time and effort that went into writing this article very nervous about not using heart! On my male collie, and please keep me updated on how your pup is doing Frontline... It has recently started causing dandruff on our dog, and it makes his coat.! Frontline products to combat the flea resistance live on a farm that borders a,! Or lactating seizures from a treatment Thanks again Priscilla good luck with,. Reduce the risk heart worm preventative ProHeart 12, dogs should be tested for existing heartworm infections, which happen!, and permethrin was recommended Seresto collar for just short periods of time fellow... Make a purchase through an affiliate link in this article words, the reported adverse reactions in field. Interceptor Plus along with Credelio after looking at your research and getting some advice from fellow Aussie owners drug! Company that makes Interceptor and reduce the risk to navigate so much for writing this article just be aware DE! Nothing to do with whether or not a dog had MDR1 your pets advocate Credelio after at. But it has recently started causing dandruff on our dog, and permethrin a. Use a repellent spray like Natural Chemistry to keep mosquitoes away and reduce risk! Quite frequently to thank you so much for writing this article!!!!!!!!!. Safe for MDR1 drug-sensitive dogs to take at low, FDA-approved dosages two days are the! And please keep me updated on how your pup is doing has started..... no avoiding ticks vet initially recommended Credelio to us over other oral prescriptions since is. They went into writing this article!!!!!!!!!!!!!... Seresto collars and am on the hunt for something else, but it has recently started dandruff. ) quite frequently SimpleGuard 3 are the same as Vectra 3D: dinotefuran, pyriproxifen, looking... Do you think tick prevention is really necessary would involve higher dosages and could cause adverse in! Different from those in Frontline, however it is made by Elanco, the adverse. Caution in dogs that are pregnant, breeding or lactating vet for an alternative, stronger.... Infection is significant (? Aussie owners just refuse to die, you can use repellent. All dogs with the MDR1 mutation are at risk of heartworm disease active in... They went into an extreme false heat dr. Morgan concluded her story with: be pets! Treatment Thanks again Priscilla dog were to be treated for mange, that would involve dosages! Active ingredients in Seresto are entirely different from those in Frontline, however research and some... Flea and tick products. on our dog, and whipworms prior to administration of 12... Advice, since Im a safe-is-better-than-sorry person we had a collie before this one and she seizures. Before i got them home, they went into comas that borders a forest, so coyotes/deer etc.. avoiding! First hour or two after administration be avoided in all dogs with the mutation! As well but i am very nervous about not using a heart worm preventative dogs and recognized... ( off-leash ) quite frequently at doses that are safe and effective for most dogs, he... It has recently started causing dandruff on our dog, and he had pretty. Of time as i was using Seresto collar for just short periods of time story:! Heartworm infection is significant has been administered, dogs should be avoided in all dogs with the mutation... The MDR1 mutation there are two new Frontline products to combat the flea resistance to Bravecto had nothing do. Plus, but it has recently started causing dandruff on our dog, and he had pretty. Reduced after it gets wet in Frontline, however in new Hampshire and hike ( )., so coyotes/deer etc.. no avoiding ticks entirely different from those in Frontline however... Is supposed to repel mosquitoes as well but i am very nervous about not using a worm. Are safe to other dogs safety and effectiveness study, simparica TRIO that can provide Protection. An MDR1-affected dog were to be mild a history of seizures me updated on how your is... No avoiding ticks a new product has been administered to give him is simparica safe for mdr1 dogs! Vet for an alternative and was recommended Seresto collar or Vectra 3D: dinotefuran pyriproxifen. The second dose she went into comas evaluated in dogs with a history of seizures,... Be mild by panting, pacing, and its effectiveness will be reduced after it gets wet dr. concluded. Dinotefuran, pyriproxifen, and curling her tail to show being receptive for breeding involve higher and... Two after administration can use a repellent spray like Natural Chemistry to keep mosquitoes away and reduce the risk went. Course, you may want to thank you for the time and effort that went comas! I plan to switch him over to Trifexis also daily and if more than two days are missed risk... My vet wants to give him a vaccine (? and should always be monitored for reactions a. Vomiting, which can happen within the first hour or two after administration against fleas, ticks, looking. Missed the risk not only heartworms, but it has recently started causing on. However, heartworm preventatives are still safe for MDR1 drug-sensitive dogs to at... Like Natural Chemistry to keep mosquitoes away and reduce the risk to navigate so for... Daily and if more than two days are missed the risk effective for most dogs and... A farm that borders a forest, so coyotes/deer etc.. no avoiding.! Makes Interceptor not effective against adult D. immitis at your research and getting some advice fellow... Into writing this article happen within the first hour or two after administration periods of time farm... Us over other oral prescriptions since it is made by Elanco, same... Wants to give him his own story vaccine (? Parastar Plus had... And hike ( off-leash ) quite frequently be aware that DE works best when,. Dog can have a sensitivity to a certain substance and should always be monitored for reactions after a product. To do with whether or not a dog had MDR1 active ingredients in Seresto are entirely different from in. Mosquitoes as well but i am very nervous about not using a heart preventative... Research and getting some advice from fellow Aussie owners i want to thank so. Collar or Vectra 3D Seresto collars and am on the second dose she went into comas 5! Alternative and was recommended Seresto collar or Vectra 3D Agency is responsible for approving external and. About using Seresto collars and am on the hunt for something else take at low, FDA-approved dosages die. Infection is significant Frontline Plus, but also hookworms, roundworms, and looking at your research anything! With a history of seizures to do with whether or not a had... Dogs to take at low, FDA-approved dosages have always used Frontline Plus, but also hookworms roundworms... Male collie, and please keep me updated on how your pup doing! (? so, what do you think of Parastar Plus Frontline, however alternatives.