I hope so! You may get sore and red palms of hands and soles of feet. The difference in my mum was amazing and just gave her some quality of life again . Registered office: 89 Albert Embankment, London SE1 7UQ. Sorry you are here, but a good place and people. You may have nosebleeds or bleeding gums after brushing your teeth. Coping with cancer can be difficult. You take capecitabine tablets in the morning. Each cycle lasts 3 weeks (21 days). Your nurse usually gives you anti-sickness (anti-emetic) drugs before the chemotherapy. Bowel (colon and rectal) cancer forum requires membership for participation - click to join. You may have a skin rash which then blisters and your skin can peel. Capecitabine comes as tablets that you swallow whole, with plenty of water. Isle of Man company number 4694F. Depending on your needs, you may have between 4 and 8 cycles. Contact your advice line as soon as possible if: Early treatment can help manage side effects better. Accessing the HOPE course through Macmillan Wellsprings story. Sometimes people who have had the live shingles vaccine can get a shingles type rash. Capecitabine can affect how the heart works. Live vaccines contain a very weak version of the illness they are vaccinating you against. Rarely, these may be life-threatening. I truly can relate with your feelings along with the experience of the financial issue. You take capecitabine tablets twice a day about 12 hours apart. These cells fight infection. A blood clot is serious, but it can be treated with drugs that thin the blood (anticoagulants). I was warned not to eat or drink, anything cold as it could swelling. First published: March 2013 and regularly updated on the Gov.UK website, Handbook of Cancer Chemotherapy (8th edition) FOLFIRINOX. Tell your doctor or nurse if you have ulcers. You can talk to your cancer doctor about your risk of having DPD deficiency before you start treatment. You might be breathlessand lookpale due to a drop in red blood cells. avoid alcohol, tobacco, and foods that irritate your mouth and throat. But these services are not available in every hospital, so you would need to ask your doctor about this. Oxaliplatin is a diaminocyclohexane (DACH)-platinum compound that is active in several solid tumor types and synergistic effects have been observed when it is combined with gemcitabine, 5-FU, or capecitabine. When the diarrhoea is better, they will tell you if you can start taking it again. This is called palmar-plantar or hand-foot syndrome. Sucking sugar-free sweets may help with this. Doing gentle exercises each day can keep your energy up. Macmillan Support Line - 0808 808 00 00, 7 days a week between 8am-8pm. The oncologist wasn't convinced the AF was caused by chemo so when I had lung mets surgically removed in 2016 he prescribedcapecitabine as a mop- up treatment. I liked Gold Bond Aloe, but everyone has their favorite. These chemotherapy drugs destroy quickly dividing cells, such as cancer cells. I actually responded well to avastin. They also check how well your liver and kidneys are working. Try to take gentle exercise, such as walking. You will not know without a test if you have DPD deficiency, as there are no symptoms. I can't comment on the treatment, as I think I had about every side effect in the book, so you don't need to hear from me, but there are several folks here on the forum, who did very well Oxaliplatin and Xeloda (I was on the Oxi and 5FU infusion) and I'm sure they will be happy to help you along your way. If you have pain or notice any change in your vision, always tell your doctor or nurse. This treatment can reduce the number of platelets in your blood. Roland KKeel This is to make sure they work as well as possible for you. Chemotherapy alone - Adjuvant capecitabine plus oxaliplatin (CAPOX) for stage II to III gastric cancer - Capecitabine plus oxaliplatin advanced esophagogastric cancer - Docetaxel, cisplatin, and fluorouracil (DCF) - Modified docetaxel, cisplatin, and fluorouracil (modified DCF) - Epirubicin, cisplatin, and fluorouracil (ECF) - Epirubicin, cisplatin, and . Maybe you'll be one who doesn't react badly. You'llneed to have some warm or hot drinks handy if you get the throat reaction. A company limited by guarantee, registered in England and Wales company number 2400969. Rather than completely stopping it you might want to chat to your oncologist about a reduction in strength . For further information about this treatment go to the electronic Medicines Compendium (eMC)website. Are you going to be on Avastin as well? Also spoil yourself a bit. Irinotecan & Capecitabine (14 day regimen) (I-Cap) Protocol V1.1. VAT no: 668265007, Coping with the news you have incurable cancer, Spring Picture Festival - Share your Spring. The side affects suck, but I'm doing much better on these drugs than I was when I was first diagnosed, so for me it's worth it. Bowel cancer means cancer that starts in the colon (large bowel) or back passage (rectum). Thank you for sharing your concern on this forum. There, that sounded less commanding. Oxaliplatin is a diaminocyclohexane (DACH)-platinum compound that is active in several solid tu-mor types and synergistic effects have been observed when it is combined with gemcitabine, 5-FU, or capecitabine.11-13 Oxaliplatin has been studied in combination with gemcitabine (GemOx) in 2 large randomized trials and, although neither demon- Make sure you drink plenty of fluids during the 24 hours following chemotherapy. Many facilities will have programs with finanical assistance, like MSK can set up payment plans and the rest to make it easier. It's been quite a while since I had chemo, but I think it was oxaliplatin that, caused the electrical shock when touching something cold. Your doctor will tell you the amount (dose) of capecitabine you need to take. In addition, oxaliplatin in combination with 5-FU This can be a: You mighthave treatmentthrough a thin short tube (a cannula) that goes into a vein in your arm. Your nurse will give you advice about managing your side effects. If you have DPD deficiency, this can affect the treatments that are available for you. Capecitabine and oxaliplatin concomitantly with radiation therapy has been evaluated before surgery in rectal cancer treatment. Sucking ice chips may sometimes help relieve mouth or throat pain. Just started FOLFOX on April 14/17. Authors Tabraiz A Mohammed 1 , Trevor Dennie, Kyle D Holen. Avoid close contact with people who have recently had live vaccines taken by mouth (oral vaccines) such as the oral typhoid vaccine. 2. If you have an intolerance to lactose, contact your doctor before taking this medicine. Its a horrible condition . INTRODUCTION; REGIMENS. Again different chemo than you, but the Oxi is the neuropathy and cold culprit. I don't know if you'll be able to find them now that winter is over. Three out of eleven lymph nodes were positive. Were here to provide physical, financial and emotional support. This treatment can reduce the number of white blood cells in your blood. Only one is growing. If cisplatin is substituted by oxaliplatin and 5-FU by . Talk to your doctor before starting treatment if you think you may want to have a baby in the future. Capecitabine, Fluorouracil, and Oxaliplatin. Taste changesmay make you go off certain foods and drinks. Tiredness and weakness (fatigue)can happen during and after treatment. Tell your healthcare team if you're finding it difficult to walk or complete fiddly tasks such as doing up buttons. Always tell your dentist you are having cancer treatment. The tube stays in place throughout the course of treatment. Macmillan Cancer Support 2020 Macmillan Cancer Support, registered charity in England and Wales (261017), Scotland (SC039907) and the Isle of Man (604). Sometimes it can cause areas of your skin to darken. There were some days when I was tired and took a nap. This is due to a drop in thenumber ofplatelets in your blood. In the UK, live vaccines includerubella, mumps, measles, BCG, yellow fever and one of the shingles vaccines called Zostavax. The oxilaplatin causes neuropathy and cold sensitivity. Each cycle lasts 3 weeks (21 days). I was less tired and able to work more. It is important to keep hands and feet well moisturised. I had rash on my neck due to tape for the catheter that runs through jugular/collarbone. The present study aimed to compare the survival outcomes, acute toxicities and surgical complications in LARC patients who received preoperative chemoradiotherapy with triweekly oxaliplatin and capecitabine . Accessing the HOPE course through Macmillan Wellsprings story. Taste changesusually get better after treatment finishes. Oxaliplatin & Capecitabine. You might have other symptoms depending on where the infection is. It can help to: Your doctor will give you anti-sickness drugs to help prevent or control sickness during your treatment. Feeling breathless can be a sign of a blood clot in the lung. The nurse or pharmacist gives you the capecitabine tablets to take at home. The big side effect from that is the possibillity of blisters and skin peeling. Very scary sight (to me). Wear gloves and I even wore flip flops in the shower to keep my feet warm. For colorectal cancer: Copyright 2000-2022 Cancer Survivors Network. Your doctor may give you anti diarrhoea medicine to take home with you after treatment. You must take tablets according to the instructions your doctor or pharmacist gives you. During treatment you usually see a cancer doctor, a chemotherapy nurse or a specialist nurse, and a specialist pharmacist. A prodrug of 5-fluorouracil (5FU), capecitabine is converted to its two active metabolites, 5-fluoro-2-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP) by carboxyesterase, cytidine deaminase and thymidine phosphorylase (present in the liver and in tumours). The virus is in the babys poo for about 2 weeks and could make you ill if your immunity is low. You should take the right dose, no moreor less. During treatment, and for a few days afterwards, it may help to: It is important to tell your doctor if you have this side effect. Your hair will usually grow back once treatment has finished butit is likely to be softer. Capecitabine and oxaliplatin drug monographs, Cancer Care Ontario. They will slow or stop your drip for a while andgive you medicine to help relieve your symptoms. I agree with the people who are saying not to stay in bed. The Macmillan Support Line offers confidential support to people living with cancer and their loved ones. After your treatment is over, most side effects start to improve. Tell your doctor if you develop: You should also tell them if any existing breathing problems get worse. Contact with others who have had immunisations-You can be in contact with other people who have had live vaccines as injections. Stage 4 means that the cancer has spread to one or more other organs. I wrote my. If you are worried about this, it is important to talk with your doctor before you start treatment. Dont have immunisations with live vaccines while youre having treatment and for up to 12 months afterwards. Or you may have lots of tiny red spots or bruises on your arms or legs (known as petechiae). You have each treatment cycle in the . No stomach cramps or anything like that. LOL. On day 1 you have oxaliplatin as an infusion. vitamins, herbal drugs and complementary therapies. A sudden feeling of cold with shivering often with a rise in temperature and sweating. Good luck to you..Dave. J Clin Oncol 2011 Apr 10;29 (11):1465-71. You can visit the electronic Medicines Compendium (eMC) for more detailed information about your treatment. This side effect can be frightening, but it should only be temporary. Brilliant news . Always tell other doctors, nurses, pharmacists or dentists that youre having this treatment. A company limited by guarantee, registered in England and Wales company number 2400969. Wash your hands after taking your tablets and capsules. I had it surgically removed on March 22. Tell your doctor if you notice any changes in your hearing. If you click my profile I have some details. Unfortunately I now have more lung tumours so waiting for an appointment to see what is recommended. I choked on a pill once because I used luke warm water. It is easier to prevent sickness than to treat it after it has started. Avoiding fatty or fried foods, eating small meals and snacks, drinking plenty of water, and relaxation techniquescan allhelp. Your hospital team may give you anti-diarrhoea drugs to take at home. They include: Numbness or tingling in fingers or toesis often temporary and can improve after youfinish treatment. Sometimes they reduce the dose. Hi Topcatrs2000 and welcome back although Im sorry to hear that youre struggling. Capecitabine has the potential to replace 5-FU/LV as the optimal combination partner for oxaliplatin at a higher cost. If you cannot get through to your doctor, call the NHS urgent advice number on 111. You may get pain or discomfort in your tummy (abdomen). I also find that I get really tired and usually need a nap in the afternoon. This means you have the drugs and then a rest to allow your body to recover. You may also find that some foods taste different from usual or that you prefer to eat spicier foods. The length of time depends on the treatment you are having. Your doctor or nurse can give you more information. Sorry to hear you have more tumours, I hope future treatment goes well,I was classed as stage 4/terminal in January 2018 and would be having palliative care,was given between 6 months and 2 years depending how treatment went,I had chemo but lasted 3 sessions as my red and white count and liver count were all over the place, after 3 months had a thermal ablation on my lung and the following month I had 30 sessions of radio on my throat, I'm still here and believe being positive and upbeat about it helps, I have my low days but then set myself targets of what I want to do,all the best, Update, decided to go ahead with the reduced Oxaliplatin and had it on Friday, maybe a bit early but my tinnitus has not got worse but my nausea is almost non exsistent and I'm eating better than the other sessions I had, think I made the right choice. Some cancer treatments can cause severe side effects. My skin is drier, but I live in a pretty dry area, so I'm used to dealing with that - lots of lotion. It helps by slowing the growth of blood vessels to provide food for the tumors. This treatment may affect your skin and nails. If you develop any signs or feel unwell after you get home, contact the hospital straight away. A low DPD level might mean you are more likely to have severe side effects from these drugs. We explain the most common side effects of this treatment here. You take capecitabine tablets in the evening. Just try to not think too long about it. Talk to your healthcare team before you stop taking or miss a dose of a cancer drug. You may need a drip to give you extra platelets. Whetheryou have a full or an empty stomach can affect how much of a drug gets into your bloodstream. Hi, I was interested to read your post as I have had dreadful tinnitus since havingoxaliplatin back in 2013/2014. FOLFOX Protocol V1.2. The second year my mum had the same combination they had to reduce her dose for other reasons but the upside was a significant reduction in her side effects with only a minimal reduction in strength . Keep them safe and out of sight and reach of children. They can give you advice and may give you creams or medicines to help. If you want to watch a silly comedy in the middle of the day, do so. . This treatment can cause changes to the lungs. Oxaliplatin forms crosslinks that inhibit DNA replication and transcription, resulting in cell death in actively dividing cells. Note that the new diet pill are often known as just one that contains associate innovative active ingredient or a novel combination of various active ingredients. It is important to tell your doctor or nurse if you have a cough or are breathless. Symptoms include a change in temperature, aching muscles, headaches, feeling cold and shivery and generally unwell. They may give you a copy of the treatment plan to take home with you. Getting to the park and walkling around got some exercise happening and just put me in a great mental state. But for some people they may never go away. Oxaliplatin Dose Capecitabine Dose >50 Full dose Give 100% 30 to 50 Full dose Give 75% <30 Omit Omit Hepatic Liver function dose Bilirubin > 3 x ULN Oxaliplatin Capecitabine Dose 100% Omit Note that significantly impaired hepatic function might be a sign of disease progression and require cessation or change of treatment. story on my blogentitled "How I Beat Stage Four Colon Cancer" if you would care to read it. So far as is permitted by law, Macmillan does not accept liability in relation to the use of any information contained in this publication or third party information or websites included or referred to in it. On the other hand, if you tend to stress and trying to address it can help reduce stress by at least tryinggo for it. And I am not going to be polite like Tru, STAY OUT OF BED!!! your side effects arent getting any better, blood clots that can be life threatening; signs are pain, redness and swelling where the clot is. It is important to use these as you are told to. I need to head out very shortly, and will try to write more later this evening. You may also have tingling, numbness, pain and dryness. She still had a brilliant outcome from treatment . ObjectiveTo compare the efficacy of adjuvant chemotherapy with six or eight cycles of S-1 plus oxaliplatin (SOX) or Capecitabine plus oxaliplatin (XELOX) after D2 resection of GC.Design and participantsWe collected 470 cases of patients with TNM stage II and III GC who underwent D2 gastrectomy in the Harbin Medical University Cancer Hospital from January 2007 to December 2017 and received six . Other people should avoid direct contact with the chemotherapy drugs. This is for 2 weeks following their vaccination. 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Company number 2400969 forms crosslinks that inhibit DNA replication and transcription, resulting cell... The park and walkling around got some exercise happening and just put me in a great mental.... On 111 read it stopping it you might have other symptoms depending on where the infection.! Therapy has been evaluated before surgery in rectal cancer treatment March 2013 regularly... Resulting in cell death in actively dividing cells get sore and red palms of hands and soles of feet some... Then a rest to make it easier or miss a dose of a blood clot the. Develop: you should also tell them if any existing breathing problems get worse after... A oxaliplatin and capecitabine forum lamisil of the shingles vaccines called Zostavax tingling in fingers or toesis often temporary and can improve after treatment... And rectal ) cancer forum requires membership for participation - click to.. Hours apart so you would Care to read it Share your Spring advice about managing your side effects....